We get a lot of mice at our house, so I've had the opportunity to try many different ways of catching them. The best I've found so far is "The Better Mousetrap" (link is below). They are big plastic mousetraps that you can set without losing a finger. The big plastic pieces make it really easy to get the mouse out without having to touch any of the nasty dead mouse bits.

Someone told me you shouldn't try and re-use mouse traps. They said that the mouse releases some sort of smell when it dies, and this will keep other mice away from the trap in the future. I've re-used my traps many times, and they keep catching mice every time, so I don't think this is really true.

I find that peanut butter works best on the trap. And then I set it up against the wall so that the mouse will be walking right into it when they are scurrying against the wall.